Avaliação dos níveis plasmáticos de melatonina em crianças com convulsões febris



Conclusões do estudo: Os níveis de melatonina foram menores em pacientes pediátricos com risco de convulsões do que em crianças saudável. São necessárias ainda mais pesquisas para verificar o papel da melatonina na fisiopatologia e no tratamento da epilepsia

Abstract (in inglese)
Pediatric Neurology - Volume 57, April 2016, Pages 51–55
Evaluation of Plasma Melatonin Levels in Children With Afebrile and Febrile Seizures.
Orçun Dabak, Demet Altun, Mutluay Arslan, Halil Yaman, Sabahattin Vurucu, Ediz Yesilkaya, Bulent Unay

Background
Melatonin modulates central nervous system neuronal activity. We compared the melatonin levels of patients with febrile and afebrile seizures during and after seizure with those of healthy controls.

Methods
We enrolled 59 individuals with afebrile and febrile seizures (mean age, 6.09 ± 4.46 years) and 28 age-, sex-, and weight-matched healthy children. Melatonin levels were measured near the time of a seizure (0 to 1 hour) and at 12 and 24 hours post-seizure, and control melatonin levels were measured from a single venous blood sample.

Results
Plasma melatonin levels increased during seizures in the study group (P < 0.001). Post-seizure plasma melatonin levels were significantly lower in the study group than in the control group (P < 0.05). Plasma melatonin levels did not differ between patients with afebrile seizures who had and had not used antiepileptic drugs. Daytime (8 AM to 8 PM) and nighttime (8 PM to 8 AM) post-seizure melatonin levels were not significantly different.

Conclusions
Melatonin levels were lower in pediatric patients prone to seizures than in healthy children and increased during seizures. Further research is needed to test the role of melatonin in the pathophysiology and treatment of epilepsy.




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